nf2 gene การใช้

• Mutations of the NF2 gene cause a human autosomal dominant disease called neurofibromatosis type 2.
• In regards to the SMARCB1 and NF2 genes, it is important to understand constitutional mutations and somatic mutations.
• Another patient exhibited a novel germline deletion of the SMARCB1, because most SMARCB1 mutations are frameshift . In this patient genetic analysis from different schwannomas indicated inactivation of both the SMARCB1 and NF2 genes.
• A mechanism involving both the SMARCB1 and NF2 genes may be responsible for the development of the disease because tumor analysis of schwannomas indicates the presence of inactivating mutations in both the SMARCB1 and NF2 genes.
• A mechanism involving both the SMARCB1 and NF2 genes may be responsible for the development of the disease because tumor analysis of schwannomas indicates the presence of inactivating mutations in both the SMARCB1 and NF2 genes.